4-Substituted- (3-substituted-1H-pyrazole-5-amino) -pyrimidine derivatives having protein kinase inhibitory activity and uses thereof

摘要

Provided are derivatives substituted by urea associated with 4-substituted-(3-substituted-1H-pyrazole-5-amino)-pyrimidine-2-amino of formula (I), wherein these compounds may selectively regulate or inhibit an information transmission process controlled by natural or variant tyrosine kinase. Also provided are preparation methods and uses of the compounds.