AVIAN INFLUENZA VIRUS ANTIGEN, AND BOOSTER IMMUNIZATION METHOD FOR AVIAN INFLUENZA VACCINE IN COMBINATION WITH MUCOSAL ADJUVANT WHICH IS EFFECTIVE THROUGH ORAL ADMINISTRATION

摘要

PROBLEM TO BE SOLVED: To provide an immunization material that enables longer maintenance of immunity induced by an initial immunization with an oil vaccine, at a high level, and that comprises an avian influenza virus antigen and a mucosal adjuvant effective for oral administration.SOLUTION: When ELISA antibody titer dropped in chickens intramuscularly inoculated with an oil vaccine, recombinant HA and NP antigens prepared using gene recombinant technology were orally administered in combination with synthetic oligo CpG as a mucosal adjuvant to the chickens. Even when the immune response induced with the oil vaccine was impaired, the antibody titer was re-induced by orally administering the recombinant HA and NP antigens, and synthetic CpG-ODN in combination.