METHOD OF EXPRESSING GENE IN TRANSGENIC BIRDS USING RETROVIRUS VECTOR AND TRANSGENIC BIRDS THUS OBTAINED

摘要

PROBLEM TO BE SOLVED: To provide a G0 transgenic chimera bird producing an antibody.SOLUTION: There are provided G0 transgenic chimeric birds which have an antibody gene having been transferred thereinto by using a retrovirus vector with a lack of replicability and produce the antibody by expressing the transferred gene; a process for producing an antibody by collecting the antibody express ed by the constructed G0 transgenic chimeric birds; and a method of constructing G0 transgenic chimeric birds by incubating fertilized bird eggs and injecting a retrovirus vector into these fertilized eggs excluding immediately after the initiation of the incubation. Namely, G0 transgenic chimeric birds having an antibody gene transferred thereinto by using a retrovirus vector with a lack of replicability and producing the antibody by expressing the thus transferred gene.