IMPROVING METHOD OF MOISTURE ABSORPTION AND FLOWABILITY OF SOLID PREPARATION FOR INTERNAL USE, SOLID PREPARATION FOR INTERNAL USE IMPROVING HYGROSCOPICITY AND FLOWABILITY, AND PRODUCTION METHOD OF THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a solid preparation for internal use improving variation in moisture absorption and flowability of the preparation with time, especially to provide a moisture absorption inhibitor and an agent improving time-dependent flowability, and to provide a solid preparation containing carnitine or salt thereof improving moisture absorption and time-dependent flowability.;SOLUTION: Dimethyl polysiloxane or a derivative thereof is effectively utilized as an agent improving moisture absorption and time-dependent flowability. Namely, the solid preparation for internal use contains: (A) at least one compound selected from carnitine or salt thereof; and (B) at least one compound selected from dimethyl polysiloxane or a derivative thereof. A method of inhibiting moisture absorption in the solid preparation for internal use and/or improving time-dependent flowability of the solid preparation for internal use comprises the step of blending (B) at least one compound selected from dimethyl polysiloxane or a derivative thereof. A method of producing the solid preparation for internal use inhibiting moisture absorption and/or improving time-dependent flowability comprises the step of blending (B) at least one compound selected from dimethyl polysiloxane or a derivative thereof. An agent inhibiting moisture absorption in the solid preparation for internal use and/or improving time-dependent flowability of the solid preparation for internal use contains (B) at least one compound selected from dimethyl polysiloxane or a derivative thereof.;COPYRIGHT: (C)2014,JPO&INPIT