Extract of Nikkei substantially free of coumarin and process for producing the same

摘要

A pharmaceutical composition comprising a substantially coumarin-free extract derived from cinnamon. Its production method including some steps: grinding the raw material, extracting raw material from previous step by maceration using a first solvent to obtain crude extract of Cinnamomum burmanii, fractionating the extracted raw material from previous step through liquid-liquid extraction using a second solvent, wherein the second solvent is immiscible with the first solvent to obtain substantially coumarin-free extract, and optionally drying the substantially coumarin-free extract. The pharmaceutical composition comprising the substantially coumarin-free extract as a single component or in a combination with suitable pharmaceutical excipient(s) to produce a pharmaceutical composition that is safe to be consumed daily and in long-term use.