AGENT FOR IMPARTING PH DEPENDANT CATIONIC PROPERTY TO LIPID MEMBRANE STRUCTURE, THE LIPID MEMBRANE STRUCTURE GIVEN THE PH DEPENDANT CATIONIC PROPERTY THEREBY, AND PRODUCTION METHOD FOR LIPID MEMBRANE STRUCTURE

摘要

PROBLEM TO BE SOLVED: To provide an agent which has YSK05 as an effective component and imparts a pH dependant cationic property to a lipid membrane structure, to provide the lipid membrane structure given the pH dependent cationic property thereby, and to provide a production method for the lipid membrane structure.;SOLUTION: An effective component of an agent is 1-methyl-4,4-bis[(9Z, 12Z)-octadeca-9,12-dien-1-yloxy]piperidine. A lipid structure impart a pH dependant cationic property to a lipid structure without giving an influence to a property such as a particle diameter and PDI of the lipid structure, improves membrane fusing performance with a biomembrane as the pH decreases, effectively involves a substance such as a siRNA and a drug, and also protects the involved substance from decomposing, etc. in a serum to stably hold it.;COPYRIGHT: (C)2014,JPO&INPIT