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MODULAR, BIOACTIVE PEPTIDES FOR BINDING NATIVE BONE AND IMPROVING BONE GRAFT OSTEOINDUCTIVITY
MODULAR, BIOACTIVE PEPTIDES FOR BINDING NATIVE BONE AND IMPROVING BONE GRAFT OSTEOINDUCTIVITY
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机译:模块化的生物活性肽,用于结合天然骨并改善骨移植物的骨诱导性
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摘要
A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a bone-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of native bone, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.
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