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PHOTOSTABLE AIE LUMINOGENS FOR SPECIFIC MITOCHONDRIAL IMAGING AND ITS METHOD OF MANUFACTURING THEREOF
PHOTOSTABLE AIE LUMINOGENS FOR SPECIFIC MITOCHONDRIAL IMAGING AND ITS METHOD OF MANUFACTURING THEREOF
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机译:用于特定线粒体成像的光稳定AIE发光剂及其制造方法
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摘要
AIE (aggregation-induced emission)-active TPE derivatives, TPE-TPP, TPE-MitoR and TPE-IQ are contemplated. These specific TPE derivatives are useful as fluorescent agents for mitochondrial imaging and as apoptosis inducers. Possessing high specificity to mitochondria, superior photostability and appreciable tolerance to microenvironment change, TPE derivatives are well-suited imaging agents for mitochondrial targeting and morphological change tracking. Because of their synthetic flexibility, TPE derivatives can be further modified as dual-functional probes for an array of applications such as sensing of ROS, metal ions, or pH change in mitochondria.
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