COMPUTER-IMPLEMENTED SYSTEM AND METHOD FOR THE PREDICTION OF CANCER RESPONSE TO GENOTOXIC CHEMOTHERAPY AND PERSONALISED NEOADJUVANT TREATMENTS (PCCP)

摘要

A method for predicting an individual's response to a treatment for cancer, the method comprising a step of assaying a biological sample from the individual to determine the abundance of a panel of two or more bio-markers comprising pro-apoptotic and/or anti-apoptotic biomarkers; inputting the abundance value for the two bio-markers into a computational model of a mitochondrial apoptosis pathway; and processing said abundance values using said computational model to provide a value to predict the individual's response to treatment.