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GASTRO-RETENTIVE DRUG DELIVERY SYSTEM FOR CONTROLLED DRUG RELEASE IN THE STOMACH AND INTO THE UPPER INTESTINES
GASTRO-RETENTIVE DRUG DELIVERY SYSTEM FOR CONTROLLED DRUG RELEASE IN THE STOMACH AND INTO THE UPPER INTESTINES
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机译:胃中和上消化道内药物控制释放的胃保留药物输送系统
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摘要
A gastro-retentive drug delivery system for controlled release of drugs in the stomach or upper gastro-intestinal track provides one or more polymers that hydrate and swell to immobilize the drug in situ in a protective, degradable envelope or cocoon. In one embodiment, oppositely charged polyelectroytes are admixed with the drug and filled in a capsule having a dissolution profile in stomach acid at body temperature. The dissolution profile of the capsule promotes formation of a poyelectrolyte gel complex. The gel complex increases retention time of the drug and reduces dosing requirements, increases absorption, reduces dose-dependent side effects, and provides reproducible, time-controlled drug residence in the GI tract.
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