Substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1h-pyrido1,2-αpyrrolo1′,2′:3,4imidazo1,2-dpyrazine-8-carboxamides

摘要

The present invention is directed to a class of substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-8-carboxamides useful as anti-HIV agents. The compounds have the formula (I-1-1):; wherein ring A is an optionally substituted hexahydro-1H-pyrrolo[1,2-c]-imidazole; R¹⁴ and R^X are independently hydrogen or optionally substituted lower alkyl; R³ is selected from various groups; R¹ is hydrogen or lower alkyl; R is halogen; m is 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof.