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Methods for treating immune-mediated Dengue Fever infections and antibody-dependent enhancement of Dengue Fever infections, including Dengue Hemorrhagic Fever and Dengue Shock Syndrome
Methods for treating immune-mediated Dengue Fever infections and antibody-dependent enhancement of Dengue Fever infections, including Dengue Hemorrhagic Fever and Dengue Shock Syndrome
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机译:治疗免疫介导的登革热感染和抗体依赖性增强登革热感染的方法,包括登革热出血热和登革热休克综合征
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摘要
Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection, are described. For example, polypeptides and other compounds can be used to inhibit binding of DF-associated, immune-complexed IgG anti-DF viron(s) or DV viral antigens to FγR, ADE of DF/DHF/DSS infections by inhibition of DF viral antigen binding to immune complexed IgG, FγR and immune complexed IgG mC1q (membrane C1q) or soluble C1q binding.
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机译:可以与免疫球蛋白分子的C H Sub> 2-C H Sub> 3裂口特异性结合的多肽和其他化合物,以及使用此类多肽和化合物抑制Fc的方法介导的病毒感染中免疫复合物的形成。例如,多肽和其他化合物可用于通过抑制DF病毒抗原来抑制DF相关的免疫复合IgG抗DF病毒或DV病毒抗原与DF / DHF / DSS感染的FγR,ADE结合与免疫复合IgG,FγR和免疫复合IgG mC1q(膜C1q)或可溶性C1q结合结合。
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