DOWNREGULATION OF SINE/ALU RETROTRANSPOSON TRANSCRIPTION TO INDUCE OR RESTORE PROLIFERATIVE CAPACITY AND/OR PLURIPOTENCY TO A STEM CELL

摘要

In certain embodiments methods are provided for inducing and/or restoring and/or maintaining a non-senescent phenotype, or aspects thereof (e.g., proliferative capacity and/or pluripotency) in a mammalian cell. The methods typically involve reducing the level or activity of SINE/Alu retrotransposon transcripts in the cell in an amount sufficient to induce or restore proliferative capacity and/or pluripotency to said mammalian cell.