MICRO-RNAS AND MICRO-RNA INHIBITORS TO MODULATE BLOOD VESSEL GROWTH, PATTERNING, TUMOR GROWTH AND MALIGNANT DISEASE AND METHOD FOR MAKING AND USING THEM

摘要

In alternative embodiments, the invention provides compositions and methods comprising use of microRNAs and microRNA inhibitors to modulate blood vessel growth (angiogenesis), e.g., act as anti-angiogenic agents, and modulate cell and tumor microenvironment patterning, cancer cell and tumor growth and malignant disease (metastasis). In alternative embodiments, the invention provides compositions and methods that can sensitize blood vessels, e.g., tumor blood vessels, to radiation and agents and chemotherapies that cause DNA damage.