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Reversible fluorescence photoswitch based on dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems
Reversible fluorescence photoswitch based on dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems
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机译:基于染料交联的树枝状纳米团簇的可逆荧光光电开关,用于活体生物系统的高对比度成像
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摘要
The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.
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