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Pharmaceutical composition containing docetaxel-cyclodextrin inclusion complex and its preparing process

机译:含多西他赛-环糊精包合物的药物组合物及其制备方法

摘要

A docetaxel inclusion complex having improved water-solubility (up to 15 mg/ml) and stability (stability constant Ka=2056 M−1-13051 M−1), comprises docetaxel and hydroxypropyl-beta-cyclodextrin and/or sulfobutyl-beta-cyclodextrin in a ratio of 1:10-150. The method includes steps as follows: docetaxel dissolved in ethanol is added into water solution of cyclodextrin via stirring, until docetaxel is completely dissolved; said solution is filtered in 0.2-04 μm microporous membrane then ethanol is removed through reduced pressure to obtain the inclusion complex in a liquid form; or ethanol, followed by water is removed through reduced pressure, then dried to obtain the inclusion complex in a solid form.
机译:具有改善的水溶性(至多15 mg / ml)和稳定性(稳定性常数Ka = 2056 M -1 -13051 M -1 )的多西紫杉醇包合物,包括多西他赛和羟丙基-β-环糊精和/或磺丁基-β-环糊精的比例为1:10-150。该方法包括以下步骤:通过搅拌将溶于乙醇的多西紫杉醇通过搅拌加入到环糊精的水溶液中直至多西紫杉醇完全溶解。所述溶液在0.2-04μm微孔膜中过滤,然后减压除去乙醇,得到液体形式的包合物。乙醇或乙醇,然后通过减压除去水,然后干燥以获得固体形式的包合物。

著录项

  • 公开/公告号US8765716B2

    专利类型

  • 公开/公告日2014-07-01

    原文格式PDF

  • 申请/专利权人 MERIDIAN LABORATORIES INC.;

    申请/专利号US201313932434

  • 发明设计人 YONG REN;JIANFENG GAO;SHUQIN YU;LING WU;

    申请日2013-07-01

  • 分类号C08B37/16;A61K31/715;

  • 国家 US

  • 入库时间 2022-08-21 16:02:13

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