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Compositions and methods for increasing production of recombinant gamma-carboxylated proteins
Compositions and methods for increasing production of recombinant gamma-carboxylated proteins
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机译:用于增加重组γ-羧化蛋白产量的组合物和方法
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摘要
Methods and cell lines for overexpressing functional gamma-carboxylated proteins are disclosed by way of genetically engineered cell lines which over-express VKORC1. Also disclosed is the antisense inhibition of expression of calumenin in conjunction with overexpression of VKORC1 which also increases expression of functional gamma-carboxylated proteins. Gamma-carboxylated proteins of interest may include blood coagulation factors such as human clotting factors IX and VII.
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