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Fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
Fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
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机译:广泛中和抗体靶向的HIV-1 gp41融合中间状态
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摘要
Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided.
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