Butyrylcholinesterase ligands as diagnostic tools and treatment for diseases of the nervous system

摘要

Compounds useful for the early diagnosis of malignant tumors, multiple sclerosis, and especially Alzheimer's Disease and related dementias; especially compounds of Formula (I) wherein R₁ is selected from the group consisting of hydrogen, cyano, fluoro, iodo, alkyl, and aryl; R₂ is selected from the group consisting of hydrogen, alkyl, and aryl; X is selected from the group consisting of CH₂, CH₂O, oxygen, OCH₂, CH₂S, SCH₂, NH, N-alkyl, and N-aryl; Y is an optional spacer group, absent or selected from the group consisting of oxygen, sulfur, NH, N-alkyl, and N-aryl; and Z is selected from the group consisting of alkyl substituted with cyano, fluoro, or iodo and aryl substituted with cyano, fluoro, or iodo. In a preferred embodiment, R₁ and R₂ are hydrogen, X is CH₂O, Y is absent, and Z is phenyl substituted with fluoro, cyano, or iodo. In some embodiments, Z is more specifically ¹⁸F-phenyl or ¹²³I-phenyl or ¹³¹I-phenyl. Other compounds are also provided.;