首页>
外国专利>
Methods of using an array of pooled probes in genetic analysis
Methods of using an array of pooled probes in genetic analysis
展开▼
机译:在遗传分析中使用一系列合并探针的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides arrays of polynucleotide probes having at least one pooled position. A typical array comprises a support having at least three discrete regions. A first region bears a pool of polynucleotide probes comprising first and second probes. A second region bears the first probe without the second probe and a third region bears the second probe without the first probe. A target nucleic acid having segments complementary to both the first and second probes shows stronger normalized binding to the first region than to the aggregate of binding to the second and third regions due to cooperative binding of pooled probes in the first region. The invention provides methods of using such arrays for e.g., linkage analysis, sequence analysis, and expression monitoring.
展开▼