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Therapeutic apyrase constructs, apyrase agents, and production methods
Therapeutic apyrase constructs, apyrase agents, and production methods
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机译:治疗性腺苷三磷酸酶构建体,腺苷三磷酸酶制剂和生产方法
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摘要
This invention provides a new class of enhanced apyrases (EN-apyrases) with superior pharmacokinetic, pharmacodynamic, and pharmacochemical properties and which can be purified using simplified procedures. The invention further provides constructs for transforming a cell to produce these EN-apyrases. The EN-apyrase construct comprises sequences encoding a signal sequence, a linker, and a soluble apyrase. Also provided are preparations of apyrases and methods for producing apyrase in culture cells and purification thereof.
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