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Method of using N-thio compounds for oligonucleotide synthesis
Method of using N-thio compounds for oligonucleotide synthesis
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机译:使用N-硫代化合物进行寡核苷酸合成的方法
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摘要
A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R1 and R2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.; 展开▼
机译:一种合成寡核苷酸的方法,该方法包括使用通式(I)的硫化剂来硫化寡核苷酸的前体的至少一个磷核苷酸间键,其中R是与S键合的芳基或杂芳基。 -通过一个环状碳原子的原子; R 1和R 2分别独立地是有机残基,优选C 1 -C 20烃残基。该方法可以进一步包括纯化寡核苷酸。还包括合成硫化剂的方法。 化学>
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