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A NEW METHOD OF USING N-THIO COMPOUNDS FOR OLIGONUCLEOTIDE SYNTHESIS
A NEW METHOD OF USING N-THIO COMPOUNDS FOR OLIGONUCLEOTIDE SYNTHESIS
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机译:使用N-硫代化合物合成寡核苷酸的新方法
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摘要
A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R1 and R2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.
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