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Peptide amphiphiles and methods to electrostatically control bioactivity of the ikvav peptide epitope
Peptide amphiphiles and methods to electrostatically control bioactivity of the ikvav peptide epitope
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机译:肽两亲物和静电控制ikvav肽表位生物活性的方法
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摘要
The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the peptide amphiphiles of the present invention have increased solubility and reduced nanofiber bundling. The molecules may be used in pharmaceutical applications, for example for in vivo administration to human patients, by increasing biological activity of the compositions toward neurite outgrowth and nerve regeneration.
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