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Oligonucleotides for detection test of polymorphism of EGFR exon 19 and use therof
Oligonucleotides for detection test of polymorphism of EGFR exon 19 and use therof
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机译:寡核苷酸用于检测EGFR外显子19多态性的检测方法和用途
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摘要
An oligonucleotide for a detection test of a polymorphism of EGFR exon 19, the oligonucleotide being at least one selected from the group consisting of a P1 oligonucleotide and a P1′ oligonucleotide, the P1 oligonucleotide having a 3′ end subjected to an extension inhibition treatment, which has an identity of at least 80% with respect to a base sequence including at least the 115th to the 123rd bases of the base sequence indicated in SEQ ID NO: 1 and has a length of from 9 to 80 bases; and the P1′ oligonucleotide having a 3′ end subjected to an extension inhibition treatment, which hybridizes under stringent conditions with a complementary strand of a base sequence including at least the 115th to the 123rd bases of the base sequence indicated in SEQ ID NO: 1 and having a length of from 9 to 80 bases.
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机译:一种用于检测EGFR外显子19多态性的寡核苷酸,该寡核苷酸为选自P1寡核苷酸和P1'寡核苷酸中的至少一种,该P1寡核苷酸的3'端经过延伸抑制处理,相对于至少包含SEQ ID NO:1所示碱基序列的第115至第123个碱基的碱基序列具有至少80%的同一性,并且其长度为9至80个碱基;以及具有延伸抑制处理的具有3'端的P1'寡核苷酸,其在严格条件下与包括至少SEQ ID NO:1所示碱基序列的第115至第123个碱基的碱基序列的互补链杂交。长度为9至80个碱基。
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