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Genetic vasectomy by overexpression of PRML-EGFP fusion protein in spermatids
Genetic vasectomy by overexpression of PRML-EGFP fusion protein in spermatids
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机译:PRML-EGFP融合蛋白在精子细胞中的过表达
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摘要
The present invention provides a genetically-modified non-human animal whose somatic and germ cells contain an exogenous gene encoding a recombinant fusion protein, wherein the presence, and expression, of said recombinant fusion protein renders said genetically-modified non-human animal sterile. Tools for generating such sterile genetically-modified non-human animal as well as methods of use thereof are also provided.
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