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Structure of the C-terminal region of the insulin receptor α-chain and of the insulin-like growth factor receptor α-chain

机译：胰岛素受体α链的C末端区域和胰岛素样生长因子受体α链的C末端区域的结构

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摘要

The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.

机译：本发明一般涉及胰岛素受体（IR）和胰岛素样生长因子 1 受体（IGF-1R）的胰岛素结合位点的结构研究。更具体地，本发明涉及包含IRα链的C端区域以及IGF-1R的相应区域的IR胞外域的低亲和力胰岛素结合位点的晶体结构，以及涉及以下方法：使用晶体和相关的结构信息来筛选和设计与IR和/或IGF-1R相互作用或调节其功能的化合物。 展开▼

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公开/公告号US8666718B2

专利类型

公开/公告日2014-03-04

原文格式PDF

申请/专利权人 MICHAEL COLIN LAWRENCE;BRIAN JOHN SMITH;JOHN GERBRANDT TASMAN MENTING;COLIN WESLEY WARD;
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申请/专利号US201013265879

发明设计人 MICHAEL COLIN LAWRENCE;BRIAN JOHN SMITH;JOHN GERBRANDT TASMAN MENTING;COLIN WESLEY WARD;
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申请日2010-03-09

分类号G01N33/48;G06G7/58;

国家 US

入库时间 2022-08-21 15:59:13

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2. 胰岛素受体α-链以及胰岛素样生长因子受体α-链的C末端区域的结构 [P] . 中国专利： CN102460175A . 2012-05-16

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