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STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR ALPHA -CHAIN AND OF THE INSULIN-LIKE GROWTH FACTOR RECEPTOR ALPHA -CHAIN
STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR ALPHA -CHAIN AND OF THE INSULIN-LIKE GROWTH FACTOR RECEPTOR ALPHA -CHAIN
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机译:胰岛素受体α-链的C末端区域和胰岛素样生长因子受体α-链的结构
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摘要
The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR alpha-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.
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