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Compositions and method for the reduction of post-operative pain
Compositions and method for the reduction of post-operative pain
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机译:减轻术后疼痛的组合物和方法
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摘要
At least three component, body-implantable, absorbable, biocompatible, putty, and non-putty pain-relieving compositions for use in surgery comprising in intimate admixture: an analgesic having local pain-relieving activity for internal relief of pain, a finely powdered bulking material, preferably less than 50 microns, e.g. the metal salts of fatty acid, hydroxyapatite, DBM, polyglycolide, polylactide, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches.;An organic liquid capable of solubilizing, dispensing or suspending the analgesic, such as esters of monohydric alcohols with aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with mono or polycarboxylic acids; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; polyhydroxy compounds and esters and ethers thereof; random or block copolymers of ethylene oxide and propylene oxide.
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机译:用于外科手术的至少三种成分,可植入身体的,可吸收的,生物相容性的,油灰和非腻子的止痛组合物,包括紧密混合的药物:具有局部止痛活性以内部缓解疼痛的镇痛药,细粉状填充物材料,优选小于50微米,例如脂肪酸,羟基磷灰石,DBM,聚乙交酯,聚丙交酯,聚己内酯,可吸收玻璃,明胶,胶原蛋白,单糖和多糖淀粉的金属盐;能够溶解,分配或悬浮止痛剂的有机液体,例如一元醇的酯与脂肪族一元羧酸; C 2 Sub> -C 18 Sub>一元醇与多元羧酸; C 8 Sub> -C 30 Sub>一元醇;生育酚及其与一元或多元羧酸的酯;游离羧酸,例如油酸,癸酸和月桂酸;二烷基醚和酮;多羟基化合物及其酯和醚;环氧乙烷和环氧丙烷的无规或嵌段共聚物。
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