Condensed Ring substituted Heterocyclic Compound, Pharmaceutical composition containing same and their use for the manufacture of a Medicament for the treatment of diseases neurogenerativas and Atherosclerosis

摘要

A Condensed Ring substituted Heterocyclic Compound of the formula (1): in which R is H or alkyl of C1 - 6; R IS h, or C1 - 6 Halo alkyl; X is - O -, - NH -, N - (alkyl C1 - 6) -, - S - O - CH2 -; n is 0, 1, 2 or 3; and when X is - CH2 -, N is 1 or 2; ar is phenyl or heteroaryl, both being of the same S substituted with one or More groups selected from the group consisting of CN, Halo, - Oh, - NH2,- nhr1, nr1r2 - 6 - alkoxy alkyl, C1, C1 and C1 haloalquilo - 6 - 6; and y is absent or is OAR -, - NH - AR, N - (alkyl C1 - 6) or - AR - AR, - (CH2) where ar is phenyl or heteroaryl, both being without a SUBSTITUTE or substituted with one or More groups selected from the group consisting of CN, Halo, - Oh, - NH2, - n Nr1r2 HR1, C1 -, alkyl - 6Alkoxy haloalquilo C1 and C1 - 6 - 6 and every time they appear, R1 and R2 are independently alkyl C1 - 6; or a pharmaceutically acceptable Salt thereof. A Pharmaceutical composition comprising the compound of the formula (1) or one of its pharmaceutically acceptable Salts and one or more pharmaceutically acceptable excipients.Use of the compound, or a pharmaceutically acceptable salts thereof, for the manufacture of a Medicament for the treatment of Neurodegenerative Diseases and Atherosclerosis.