Heterocyclic Derivatives of pyrimidine compounds as inhibitors of Janus activated Kinases (JAK)

摘要

1. This claim refers to a class of pyridine compounds, pharmaceutically acceptable salts thereof, pharmaceutical ingredients containing such compounds and their use in medicine.or a tautomer thereof or a pharmaceutically acceptable salt or its hydrate characterized in that R1 represents optionally substituted groups selected from C3-8 cycloalkyl, aralkyl, heteroaralkyl, C1-6 alkyl, C2-4 alkenyl, and C2-4 alkynyl; R 2 represents optionally substituted groups selected from C 1-6 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-8 cycloalkyl, aryl, a 4-7 membered heterocyclic ring having 1-2 heteroatoms independently selected from N, O or S; R3 at each occurrence independently represents hydrogen, halogen, nitro, cyano, - (CH2) rC (O) R4, - (CH2) rC (O) OR4, -N (R4) 2, -NH (CH2) rC (O) R4, -NH (CH2) rC (O) OR4,-NH (CH2) R-S (o) 2O R4, R represents an integer of 0-2; R4 independently represents hydrogen in each substance, alternative groups selected from C1-6 tar, alquenilo c2-4 and c2-4, and c2-4 tar; or NR5 and R6 independently represent hydrogen; Selective substitution of C1-6 tar, alquenilo c2-4, C-4 tar, C3-8 cyclopropene, arilo, heterocycle consisting of 4-7 members consisting of 1-2 heteroatoms independent of N or s, or ring R5, R6 with n,Optionally substituted and optionally containing one or more heteromorphic atoms selected from n or s; X rsqoe; for O lsqoe; M rsqoe; for integers 0-4.