Azaindoles substituted with either triazine or pyrimidine useful as inhibitors of janus kinases consisting of JAK1, JAK2, JAK3, and TYK2

摘要

Disclosed are compounds of formula (I) and methods for their preparation. The compounds have an azaindole core and are substituted with either a pyrimidine or triazine moiety. Additionally, R1 is NR-CR2-C(O)-NR2 X is N or CR The compounds of formula (I) are useful as inhibitors of Janus kinases, a family of tyrosine kinases consisting of JAK1, JAK2, JAK3 and TYK2. The compounds are therefore useful as pharmaceuticals for treating a disease or condition such as a proliferative disorder, a cardiac disorder, a neurodegenerative disorder, an autoimmune disorder, a condition associated with organ transplantation, an inflammatory disorder, or an immunologically mediated disorder. In particular the pharmaceuticals are useful for treating asthma, transplant rejection and rheumatoid arthritis.