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Preparation of Enteric microcapsules by Ionic gelation of Alginate containing Diclofenac or one of its Salts and Pharmaceutical composition that contains multiparticulada
Preparation of Enteric microcapsules by Ionic gelation of Alginate containing Diclofenac or one of its Salts and Pharmaceutical composition that contains multiparticulada
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机译:通过含双氯芬酸或其盐之一的藻酸盐的离子凝胶化制备肠溶性微胶囊,以及含有多颗粒的药物组合物
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摘要
1. A procedure that can be used to produce uncoated intestinal microcapsules containing xylene or an oral salt (sodium, potassium, epolamine) with satisfactory anti-inflammatory activity and low gastric aggression; and a pharmaceutical component containing the substance. The process includes four steps: (a) preparation of water ethanol mixture containing sodium alginato in the presence of surface activity and sodium carbonate, adding xylene or one of the previously completely dissolved salts;(b) The former solution (water-soluble calcium salt) solution is slowly incorporated into the solution to produce a gel; (c) the microcapsules separated from 1 / 1000 sodium alginato aqueous solution are revived; and (d) the resulting microcapsules are separated and dried and screened through 1000 and 1000 mesh sieves; 250 mmThe part between the two mesh mesh was selected to make the selected drug components, while the other parts were excluded. The drug composition contained in the microcapsule (to determine the local adhesion) can be in the form of oral capsule, compression agent, chewing tablet or water suspension before the patient takes it. It also refers to the pharmaceutical components of intestinal microcapsules containing uncoated polymers of phenol dichloride related to proton pump inhibitors (e.g,omeprazol) industrialmente conocidos y disponibles bajo la forma de pellets ent ricos en composici n farmac utica de uso oral que contiene ambos principios activos en la misma composici n Reivindicaci n 1 Procedimiento de elaboraci n de microc psulas ent ricas de alginato de calcio de composici n polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate; polyoxyethylene sorbitan monolaurate; and sodium bicarbonate at a temperature below 60 ° C; B) incorporate the solution obtained in A) into a solution of calcium chloride controlling the temperature below 60 ° C, during the whole process; C) resuspend the microcapsules formed and isolated without prior drying in sodium alginate solution between 0.05 and 0.1%,a. Vibrate at room temperature for 30 to 120 minutes; (d) by filtration, drying and continuous screening of 1000 mm and 250 mm meshes, only part of the microcapsules collected and sized between the two meshes is selected to make the drug composition; in this case, the microcapsules obtained e. The content of selected active principle was more than 55%;(e) Alternatively, the microcapsules thus obtained are transformed into microcapsules released in the growing period. Claim 12: an oral polychlorinated biphenyls pharmaceutical ingredient in the form of a capsule, characterized by the presence of 25-100 mg of benzene dichloride or one of its sodium, potassium or Cyclopropylamine salts, in the form of an intestinal microcapsule manufactured in accordance with claims 1-11.
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