METHOD AND USE FOR VERIFICATION OF ASSEMBLY ERRORS IN GENOMES

摘要

The present invention is a method for verifying assembly errors in genomes of sequenced or synthetically produced organisms that use frequency relationships between nucleotide sequence fragments of a genome. . The method has applications in error checking in a genome assembled from fragments derived from different types of sequencing technologies and assist in the construction of synthetic genomes, for example. It can be used for compression of genetic material, since the frequency ratios determined by the method allow to reduce the complexity of nucleotide sequences, so as to represent their content in a compressed manner, thus reducing the space required for their storage.