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METHOD FOR PRODUCING PRASUGREL HYDROCHLORIDE, PRASUGREL HYDROCHLORIDE, PHARMACEUTICAL COMPOSITION, AND, USE OF A PRASUGREL HYDROCHLORIDE.
METHOD FOR PRODUCING PRASUGREL HYDROCHLORIDE, PRASUGREL HYDROCHLORIDE, PHARMACEUTICAL COMPOSITION, AND, USE OF A PRASUGREL HYDROCHLORIDE.
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机译:制备普拉格瑞盐酸盐,普拉格瑞盐酸盐,药物组合物以及使用普拉格瑞盐酸盐的方法。
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摘要
An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like. In the formulae, R represents a protecting group for a hydroxyl group. A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.
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