Method for Treatment of Dysfunction of neurotransmission and other States associated with the activity of mglur4en involves use of Derivatives of pyrazole Heterocyclic compounds with other Heterocyclic Compounds; condensate; compositions containing same and use in the treatment of Neurological dysfunction.

摘要

Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.