Method and to improve the efficacy and / or reduce the side effects of a suboptimal pharmacotherapy administered form comprising administering a Pharmaceutical composition hexitol replaced; Pharmaceutical; Combination; use for treating proliferative diseases.

摘要

The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol.