Aqueous Composition of immunoglobulin (IgG) Stable during Storage, which comprises a IgG, histidine, Alkaline pH and cation method to stabilize a given Composition of IgG.

摘要

The present invention provides, among other aspects, storage stabile aqueous formulations of labile proteins at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing a labile therapeutic protein composition at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of labile proteins at mildly acidic to neutral pH useful for parenteral administration.