Procedure for the synthesis of Ivabradine and its Addition salts with a pharmaceutically acceptable acid by reaction of lactamizacion a compound derived from acetic acid, in the presence of a coupling Agent and a base in an organic Solvent; and intermediaries used compounds S in this procedure.

摘要

Preparing 2-[3-[(3,4-dimethoxy-7-bicyclo[4.2.0]octa-1(6),2,4-trienyl)methyl-methyl-amino]propyl]-6,7-dimethoxy-1,4-dihydroisoquinolin-3-one (I) comprises subjecting 2-[2-[2-[3-[(3,4-dimethoxy-7-bicyclo[4.2.0]octa-1(6),2,4-trienyl)methyl-methyl-amino]propylamino]ethyl]-4,5-dimethoxy-phenyl]acetic acid (II) to a lactamization reaction, in the presence of a coupling agent and a base, in an organic solvent, to yield (I), which is converted into an addition salt with an acid consisting of e.g. hydrochloric acid, hydrobromic acid, sulfuric acid and phosphoric acid and into hydrates of salt. Preparing 2-[3-[(3,4-dimethoxy-7-bicyclo[4.2.0]octa-1(6),2,4-trienyl)methyl-methyl-amino]propyl]-6,7-dimethoxy-1,4-dihydroisoquinolin-3-one (I) comprises subjecting 2-[2-[2-[3-[(3,4-dimethoxy-7-bicyclo[4.2.0]octa-1(6),2,4-trienyl)methyl-methyl-amino]propylamino]ethyl]-4,5-dimethoxy-phenyl]acetic acid (II) to a lactamization reaction, in the presence of a coupling agent and a base, in an organic solvent, to yield (I), which is converted into an addition salt with an acid consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, acetic acid, trifluoroacetic acid, lactic acid, pyruvic acid, malonic acid, succinic acid, glutaric acid, fumaric acid, tartaric acid, maleic acid, citric acid, ascorbic acid, oxalic acid, methanesulfonic acid, benzenesulfonic acid and camphoric acid and into hydrates of salt. Independent claims are included for: (1) the 2-[2-[2-[3-[(3,4-dimethoxy-7-bicyclo[4.2.0]octa-1(6),2,4-trienyl)methyl-methyl-amino]propylamino]ethyl]-4,5-dimethoxy-phenyl]acetic acid (II); (2) 2-[2-[2-[3-[(3,4-dimethoxy-7-bicyclo[4.2.0]octa-1(6),2,4-trienyl)methyl-methyl-amino]propylamino]ethyl]-4,5-dimethoxy-phenyl]acetonitrile (V); (3) 2-[2-[2-(3-chloropropylamino)ethyl]-4,5-dimethoxy-phenyl]acetonitrile (VI); (4) 3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]-1-propanol; (5) N-{2-[2-(cyanomethyl)-4,5-dimethoxyphenyl]ethyl}-beta -alaninate ethyl oxalate; and (6) (2-{2-[(3-hydroxypropyl)amino]ethyl}-4,5-dimethoxyphenyl)acetonitrile. ACTIVITY : Cardiant; Vasotropic; Antianginal. MECHANISM OF ACTION : None given.