Polypeptide variant of FGF21 multimer; he understands; Pharmaceutical composition that comprises; and Use thereof for treating one or more Disorders associated with FGF21.

摘要

The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.