Di (fluoropropyl) derivatives - 1,4-benzodiazepines, NOTCH inhibitors; crystalline compounds; pharmacological synthesis including these compounds; pharmacological binding; and uses for cancer treatment.

摘要

F amp; oacute; n refers to compounds of F amp; oacute; rmua (1) or Prof amp; Aacute; coding of these compounds; R1 es-ch 2cf3 o-ch 2ch2cf3;R2 ES -CH 2CF3, -CH 2CH 2121`3 O -C1-1 2 C1-1 2CH2CF3;R3 is h-o-ch3;Each rfmo is an independent F, CI, CN, och 3 and / or nhch 2ch20c1-13;Z is 0, 1 or 2 Tambi amp; eacute; N M amp; eacute; all compounds used to inhibit the Notch receptor and efficacy and ampere synthesis; eacute; includes props for these compounds. These compounds are the tiles; oacute; n or progressive amp; oacute; n; Aacute; reas treatment and amp; eacute; such as C amp; Aacute; NCER. / P in the treatment, prevention and AMP;