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Methods to detect Human Papillomavirus and provide forecast for squamous cell carcinoma of Head and Neck
Methods to detect Human Papillomavirus and provide forecast for squamous cell carcinoma of Head and Neck
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机译:检测人乳头瘤病毒的方法并提供头颈部鳞状细胞癌的预测
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摘要
Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described. An exemplary method for diagnosing head and neck squamous cell carcinoma (HNSCC) in a subject may comprise assaying a saliva sample from the subject for the presence of total protein, solCD44, and HPV, and using the combination of total protein, HPV, and CD44 levels in a multivariate analysis to determine a combined score, whereby an increase in score above a cut-off point distinguishes subjects with HNSCC, or an elevated risk of future occurrence thereof, from subjects without HNSCC or at low risk of future occurrence thereof.
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