methods to detect human papillomavirus and provide prognosis for head and neck squamous cell carcinoma

摘要

abstract methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described. an exemplary method for diagnosing head and neck squamous cell carcinoma (hnscc) in a subject may comprise assaying a saliva sample from the subject for the presence of total protein, solcd44, and hpv, and using a combination of total protein, hpv, and cd44 levels in a multivariate analysis to determine a combined score, whereby an increase in score above a cut-off point distinguishes subjects with hnscc, or an elevated risk of future occurrence thereof, from subjects without hnscc or at low risk of future occurrence thereof. -------------------------------------------------- -------------------------------------------------- ------- Translation from abstract patent summary: "Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma". Methods and kits for diagnosing and determining the prognosis of head and neck squamous cell carcinoma are described. An exemplary method for diagnosing head and neck squamous cell carcinoma (hnscc) in an individual may include analyzing an individual's saliva sample for the presence of total proteins, solcd44 and hpv and using the combination of protein levels. totals, hpv, and cd44 in a multivariate analysis to determine a combined score, whereby an increase in score above a cutoff distinguishes individuals with hnscc, or a high risk of future occurrence, from individuals without hnscc or low risk of future occurrence.