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Copolymers of hydromorphine and benzoic acid of benzoic acid and isoprotic acid derivatives, preamble, preparation method and use method
Copolymers of hydromorphine and benzoic acid of benzoic acid and isoprotic acid derivatives, preamble, preparation method and use method
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机译:苯甲酸和异质子酸衍生物的氢吗啡和苯甲酸的共聚物,前言,制备方法和使用方法
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摘要
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5--epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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