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BENZOIC ACID, BANZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHINE, PRODRUGS, METHODS OF MAKING AND USE THEREOF
BENZOIC ACID, BANZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHINE, PRODRUGS, METHODS OF MAKING AND USE THEREOF
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机译:苯甲酸,苯甲酸衍生物和氢鸟嘌呤的杂芳族羧酸共轭物,产品,制备方法和用途
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摘要
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5--epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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