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VEGETABLES CONTAINING MORPHOLINUM AS RESPONSIBILITIES FOR THE DESCRIPTION OF THE SUBSTANCE YOUTH

机译:含有吗啡的蔬菜是描述青年物质的责任

摘要

This invention concerns gasimidazoles containing morpholinyl which have an inhibitory effect on the replication of the respiratory tract cell virus and which are of type (I),a pimp,N-oxide,added salt,Quaternary amines,a metallic complex or a solid-chemical isomer of this form where G is a direct link or voluntarily substituted C1-10alkanediyl; R1 is Ar1 or a monocyclic or bicyclic heterocycle,Q is R7, pyrrolidine is R7-substituted, piperidyl is R7-substituted or homoperidine-substituted R7-substituted; one of R2a and R3a is selected from horse,optional mono- or poly-substituted C1-6alkyl,optional mono- or poly-substituted C2-6alkenyl,Nitro,hydroxy,Ar2, N(R4aR4),N(R4aR4)sulfonyl,N(R4aR4b)carbide,C1-6alkyloxy,A2oxy,Ar2C1-6alkyloxy,carboxyl,C1-6alkyloxycarbonyl,or -C(=Z)Ar2; and the other from R2a and R3a is hydrogen; if R2a is different from hydrogen then R2b is hydrogen,C1-6alkyl or equine and torR3b is hydrogen; if R3a is different from hydrogen then R3b is hydrogen,C1-6alkyl or equine and R2b is hydrogen. It also concerns their preparation and compositions containing these compounds,and their use as medicinal products.
机译:本发明涉及含有吗啉基的咪唑并对呼吸道细胞病毒的复制具有抑制作用,并且是(I)型,皮条,N-氧化物,加盐,季胺,金属配合物或固体化学物质。这种形式的异构体,其中G是直接连接的或自愿取代的C1-10烷二基; R1是Ar1或单环或双环杂环,Q是R7,吡咯烷是R7取代的,哌啶基是R7取代的或高哌啶取代的R7取代的; R 2a和R 3a之一选自马,任选的单或多取代的C 1-6烷基,任选的单或多取代的C 2-6烯基,硝基,羟基,Ar 2,N(R 4aR 4),N(R 4 a R 4)磺酰基,N (R4aR4b)碳化物,C1-6烷氧基,A2氧基,Ar2C1-6烷氧基,羧基,C1-6烷氧基羰基或-C(= Z)Ar2; R2a和R3a中的另一个是氢;如果R 2a与氢不同,则R 2b为氢,C 1-6烷基或马,且tor R3b为氢;如果R 3a与氢不同,则R 3b为氢,C 1-6烷基或马,且R 2b为氢。它还涉及它们的制备和含有这些化合物的组合物,以及它们作为药物的用途。

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