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Process for enzymatic conversion of racemic 2-isobutylsuccinonitrile into 3-cyano-5-methylhexanoic acid and further converting it into pregabalin
Process for enzymatic conversion of racemic 2-isobutylsuccinonitrile into 3-cyano-5-methylhexanoic acid and further converting it into pregabalin
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机译:外消旋的2-异丁基丁二腈转化为3-氰基-5-甲基己酸并将其进一步转化为普瑞巴林的方法
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摘要
The present invention is directed to a regio- and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
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