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Nucleic acid constructs comprising choroid plexus specific promoters for expressing secreted neuropeptides in the brain and pharmaceutical compositions comprising same
Nucleic acid constructs comprising choroid plexus specific promoters for expressing secreted neuropeptides in the brain and pharmaceutical compositions comprising same
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机译:包含用于表达大脑中分泌的神经肽的脉络丛特异性启动子的核酸构建体和包含该构建体的药物组合物
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摘要
A nucleic acid construct and construct system are disclosed. The nucleic acid construct and system comprise a regulatory sequence which regulates inducible expression of a polypeptide of interest, the regulatory sequence comprising a choroid plexus specific promoter, with the proviso that the choroid plexus specific promoter is not a transthyretin promoter. Pharmaceutical compositions comprising same and uses thereof are also disclosed.
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