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Diblock copolymers and uses thereof in inhibitng gene expression or for intracellular delivery of a polynucleotide
Diblock copolymers and uses thereof in inhibitng gene expression or for intracellular delivery of a polynucleotide
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机译:二嵌段共聚物及其在抑制基因表达或细胞内递送多核苷酸中的用途
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摘要
Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
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