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DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS

机译:双嵌段共聚物和多核苷酸复合物可用于细胞

摘要

pDescribed herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic./p [WO2009140427A2]
机译:在此描述的是共聚物,以及制备和利用这种共聚物的方法。这样的共聚物具有至少两个嵌段:第一嵌段具有至少一个在生理pH下为亲水性的单元,第二嵌段具有疏水基团。该第二嵌段进一步具有至少一个单元,该单元具有在大约生理pH下为阴离子的基团。所述共聚物破坏细胞膜,包括细胞外膜,细胞内膜,囊泡,细胞器,内体,脂质体或红细胞。优选地,在某些情况下,共聚物破坏膜并进入细胞内环境。在特定的例子中,该共聚物是内溶的。 [WO2009140427A2]

著录项

  • 公开/公告号IN294478B

    专利类型

  • 公开/公告日2018-03-23

    原文格式PDF

  • 申请/专利权人

    申请/专利号IN8578/DELNP/2010

  • 发明设计人

    申请日2009-05-13

  • 分类号

  • 国家 IN

  • 入库时间 2022-08-21 12:51:33

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